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  • Pegfilgrastim prophylaxis is associated with a lower risk of . . .
    Prophylactic use of recombinant human G-CSF such as daily filgrastim and once-per-cycle pegfilgrastim may reduce the incidence of febrile neutropenia This comparative study examined the effect of pegfilgrastim versus daily filgrastim on the risk of hospitalization
  • Efficacy and safety analysis of once per cycle pegfilgrastim . . .
    In this prospective pilot study, we compared the efficacy and safety profiles of pegfilgrastim administered subcutaneously once per cycle and lenograstim administered subcutaneously daily six times per cycle, for primary neutropenia prophylaxis in women with breast cancer receiving adjuvant anthracycline-based chemotherapy
  • Safety and efficacy of alternating treatment with EP2006, a . . .
    In line with these suggestions, PIONEER included multiple switches; switching at each cycle is comparable to how switches are made in real-world use; FN is an endpoint that can be grouped over cycles 2–6 to assess the effect of switching; and immunogenicity was assessed
  • Evaluation of efficacy and safety of pegfilgrastim when given . . .
    A generalized linear mixed-effects model with fixed effects for pegfilgrastim delivery method, elapsed days between pegfilgrastim and chemotherapy (fixed categorical effect for 12, 13, 14 days), and ANC at subsequent cycle was fitted to the change in ANC between chemotherapy cycles
  • Pegfilgrastim Can Be Safely Administered on Same Day as . . .
    In cycles with prophylactic pegfilgrastim, dose reductions or delays occurred in 13 8% of cycles with reference pegfilgrastim and 10 6% of cycles with the pegfilgrastim biosimilar
  • Filgrastim therapy: a bone of contention | Blood | American . . .
    Fortunately, those who were treated with filgrastim to reduce adverse effects of chemotherapy had remission and overall survival rates that were superior to those without treatment 6 Filgrastim has been used in an adult cohort to drive blasts into cell cycle for enhanced cytarabine cytotoxicity
  • A systematic literature review of the efficacy, effectiveness . . .
    In chemotherapy-induced neutropenia (CIN), filgrastim vs placebo or no treatment significantly reduced febrile neutropenia incidence (RR 0 63, 95% CI 0 53–0 75) and grade 3 or 4 neutropenia incidence (RR 0 50, 95% CI 0 37–0 68) The most commonly reported adverse event (AE) with filgrastim was bone pain (RR 2 61, 95% CI 1 29–5 27 in CIN)


















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