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  • Pectinase responsive nanoplatform for oral targeted delivery 5 . . .
    The nanoplatform showed the characteristic of acid resistance, pectinase responsive drug release, low cytotoxicity, and effective targeting via CD44 receptors
  • Pectinase responsive nanoplatform for oral targeted delivery . . .
    The nanoplatform showed the characteristic of acid resistance, pectinase responsive drug release, low cytotoxicity, and effective targeting via CD44 receptors
  • Pectinase responsive nanoplatform for oral targeted delivery 5 . . .
    The nanoplatform showed the characteristic of acid resistance, pectinase responsive drug release, low cytotoxicity, and effective targeting via CD44 receptors In a DSS-induced mouse colitis model, A-Z@cHP significantly improved body weight, disease activity index, colon length, and colonic barrier while reducing inflammation by restoring the
  • 【创新前沿】Chemical Engineering Journal和Carbohydrate . . .
    相关成果以“An anti-miR-301a and zinc coordination driven nanozyme loaded in nanoparticle for oral therapy of inflammatory bowel disease based on colitis microenvironment regulation”为题发表在国际权威学术期刊Chemical Engineering Journal上。
  • Oral colon-targeted responsive chitosan pectin-based . . . - Nature
    To address these challenges, oral colon-targeted drug delivery systems (OCDDSs) have been developed with the aim of specifically releasing medication in the colon
  • 陈学思院士团队《AM》： 构建多级合作的纳米平台用于蛋白 . . .
    可胞内活化的蛋白质与化疗药剂的联合使用被认为是一种极具前景的协同抗癌策略。 然而，目前依旧缺乏理想的纳米载体用以将两种物化性质截然不同的药物递送到肿瘤细胞内并进行可控的胞内释放，严重阻碍了这类联合治疗策略的进一步生物医学转化。 针对这一问题， 中科院长春应化所的陈学思院士和肖春生副研究员等人精心设计了mPEG-b-PGCA-b-PGTA三嵌段共聚物，并以此构建多级合作的药物递送纳米平台。 基于此平台，研究实现了亲水性核糖核酸酶A（RNase A）和疏水性化疗药物 DOX 的高效胞内共递送，在体外和体内实验中都取得了良好的协同抗癌效果。
  • 检索结果 · 华东理工大学机构知识库
    In this study, six novel salts of HDZ were synthesized and characterized to explore their potential as superior solid forms with improved physicochemical properties for hypertension treatment or other applications
  • Advanced oral drug delivery systems for gastrointestinal targeted . . .
    This review highlights the characteristics and precise targeting mechanisms of ODDSs It first examines the unique properties of each gastrointestinal compartment, including the stomach, small intestine, intestinal mucus, intestinal epithelial barrier, and colon





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