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Klotho查看　Klotho　在百度字典中的解释百度英翻中〔查看〕
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  • Klotho Variant Cuts ApoE4’s Alzheimer Risk by a Third
    A meta-analysis of 22 cohorts seems to leave little doubt that variants of the longevity gene klotho protect against dementia—at least in people unfortunate enough to have inherited an ApoE4 allele Researchers led by Michael Belloy, Stanford University, calculated that cognitively normal APOE4
  • Klotho VS Variant Preserves Memory by Preventing Tangles
    High klotho levels associate with longer life and sharper cognition (Dec 2007 conference news; May 2013 conference news; May 2014 news) The protective VS variant occurs in about 25 percent of the population It comprises two SNPs, F352V and C370S, that are inherited together
  • Is Klotho’s Partner FGF23 a Cognition Protein? - ALZFORUM
    The longevity gene klotho keeps memory keen, but how? New research raises the possibility that it might influence cognition through its signaling partners FGF23 and the fibroblast growth factor (FGF) receptor In the March 7 eNeuro, Gwendalyn King and colleagues at the University of Alabama
  • Impact of APOE, Klotho, and sex on cognitive decline with aging. | ALZFORUM
    Shibata K, Chen C, Tai XY, Manohar SG, Husain M Impact of APOE, Klotho, and sex on cognitive decline with aging Proc Natl Acad Sci U S A 2025 Feb 11;122 (6):e2416042122 Epub 2025 Feb 4 PubMed Recommends Please login to recommend the paper
  • Identification of the enzymatic cleavage relationship between anti . . .
    Gao X, Sun Z, Hu J, Li Y, Deng Q, Li R Identification of the enzymatic cleavage relationship between anti-aging protein α-Klotho and Alzheimer's disease biomarker BACE1
  • Association of Klotho-VS Heterozygosity With Risk of . . . - ALZFORUM
    This is an interesting study by Belloy and colleagues, which reports an association between Klotho-VS heterozygosity (KL-VS HET+) and apolipoprotein 4 (APOE4) allele carriage, with risk for conversion to Alzheimer’s disease (AD) and β-amyloid (Aβ) pathology Specifically, they report that in APOE4 carriers, those who were KL-VS HET+ showed a reduced risk of converting to AD, higher CSF Aβ
  • Relationship of Klotho with cognition and dementia: Results from the . . .
    Wu Y, Lei S, Li D, Li Z, Zhang Y, Guo Y Relationship of Klotho with cognition and dementia: Results from the NHANES 2011-2014 and Mendelian randomization study
  • APOE C130R (ApoE4) - ALZFORUM
    Klotho-VS, a set of two polymorphisms, F352V and C370S, in the longevity gene Klotho, offers an example of a distant modulator In heterozygous form, Klotho-VS cuts APOE4 AD risk by approximately a third (Erickson et al , 2019; Belloy et al , 2020; Apr 17 news) How it accomplishes this remains uncertain
  • Only in Old Mice, a Touch of Cannabinoid Helps Memory
    In old mice, THC treatment increased histone H3 and H4 acetylation generally, and also specifically at the klotho and BDNF promoters Increased acetylation appears necessary for the effects of THC on both gene expression and behavior, because treating mice with the histone acetylase inhibitor anacardic acid negated THCs memory-enhancing effects
  • Mutations Database | ALZFORUM
    This database is a repository of variants in genes implicated in Alzheimer’s disease (AD) Currently, it includes the three genes associated with autosomal-dominant AD (APP, PSEN1, PSEN2) plus four genes associated with AD through association studies or pathology (APOE, MAPT, SORL1, and TREM2) The goal is to provide a comprehensive list of variants in these genes that have been reported in





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